LITAF Antikörper

Produktnummer ABIN7229412

Der Kaninchen Polyklonal anti-LITAF Antikörper wird verwendet zum Nachweis von LITAF in Proben von Human, Maus und Ratte. Er wurde validiert für WB und ELISA.

Kurzübersicht für LITAF Antikörper (ABIN7229412)

Target: LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Factor (LITAF))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LITAF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-LITAF Antikörper

Verwendungszweck: LITAF Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of LITAF protein

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human LITAF protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu LITAF

Target: LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Factor (LITAF))

Andere Bezeichnung: LITAF

Hintergrund: Rabbit Anti-LITAF Polyclonal Antibody,Small integral membrane protein of lysosome/late endosome, p53-induced gene 7 protein,Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. LITAF encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of LITAF is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in LITAF cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for LITAF.,LITAF

Molekulargewicht: observerd band 17kDa

Gen-ID: 9516

UniProt: Q99732

Pathways: Cellular Response to Molecule of Bacterial Origin