LIFR Antikörper (Internal Region)

Produktnummer ABIN7218712

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch LIFR in WB, IHC und ELISA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für LIFR Antikörper (Internal Region) (ABIN7218712)

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LIFR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-LIFR Antikörper

Bindungsspezifität: Internal Region

Verwendungszweck: Rabbit Anti-LIFR Polyclonal Antibody

Spezifität: LIFR Polyclonal Antibody detects endogenous levels of LIFR protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human LIFR

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu LIFR

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Andere Bezeichnung: LIFR

Hintergrund: LIFR, Leukemia inhibitory factor receptor, LIF receptor, LIF-R, CD118LIFR encodes leukemia inhibitory factor receptor alpha that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5,8)(p13,q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.

Molekulargewicht: 120kD

Gen-ID: 3977

UniProt: P42702

Pathways: JAK-STAT Signalweg, Growth Factor Binding