Leptin Receptor Antikörper (pTyr1141)

Produktnummer ABIN7213352

Der Kaninchen-Polyklonal Anti-Leptin Receptor-Antikörper wurde für WB und ELISA validiert. Er ist geeignet zum Nachweis von Leptin Receptor in Proben aus Human und Maus. }

Kurzübersicht für Leptin Receptor Antikörper (pTyr1141) (ABIN7213352)

Target: Leptin Receptor (LEPR)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Leptin Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Leptin Receptor Antikörper

Bindungsspezifität: pTyr1141

Verwendungszweck: Ob-R (phospho Tyr1141) Polyclonal Antibody

Spezifität: Phospho-Ob-R (Y1141) Polyclonal Antibody detects endogenous levels of Ob-R protein only when phosphorylated at Y1141.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human Ob-R Phospho-Tyr1141

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu Leptin Receptor

Target: Leptin Receptor (LEPR)

Andere Bezeichnung: Ob-R

Hintergrund: Rabbit Anti-Ob-R (phospho Tyr1141) Polyclonal Antibody,LEPR, DB, OBR, Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD antigen CD295,Leptin receptor encoded by LEPR belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. Leptin receptor is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in LEPR have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for LEPR. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).,Leptin receptor

Molekulargewicht: observerd band 132kDa

Gen-ID: 3953

UniProt: P48357

Pathways: JAK-STAT Signalweg, AMPK Signaling, Feeding Behaviour