LGMN Antikörper (AA 60-140)

Produktnummer ABIN7229390

Dieser Anti-LGMN Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von LGMN in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für LGMN Antikörper (AA 60-140) (ABIN7229390)

Target: LGMN (Legumain (LGMN))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LGMN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-LGMN Antikörper

Bindungsspezifität: AA 60-140

Verwendungszweck: LGMN Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of LGMN protein

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human LGMN protein at AA range: 60-140

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu LGMN

Target: LGMN (Legumain (LGMN))

Andere Bezeichnung: LGMN

Hintergrund: Rabbit Anti-LGMN Polyclonal Antibody,Legumain, Asparaginyl endopeptidase, Protease, cysteine 1,LGMN encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of LGMN may be associated with the majority of solid tumor types. LGMN has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.,LGMN

Molekulargewicht: observerd band 47kDa

Gen-ID: 5641

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades