IBTK Antikörper (AA 410-490)

Produktnummer ABIN7229004

Der Kaninchen Polyklonal Anti-IBTK Antikörper wurde für WB und ELISA validiert. Er ist geeignet, IBTK in Proben von Human zu detektieren.

Kurzübersicht für IBTK Antikörper (AA 410-490) (ABIN7229004)

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IBTK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-IBTK Antikörper

Bindungsspezifität: AA 410-490

Verwendungszweck: IBTK Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of IBTK protein

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human IBTK protein at AA range: 410-490

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu IBTK

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Andere Bezeichnung: IBTK

Hintergrund: Rabbit Anti-IBTK Polyclonal Antibody,Inhibitor of Bruton tyrosine kinase, IBtk,IBTK (Inhibitor Of Bruton Tyrosine Kinase) is a Protein Coding gene. Diseases associated with IBTK include Agammaglobulinemia. Among its related pathways are B cell receptor signaling pathway (KEGG). Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by IBTK binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. IBTK has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,IBTK

Molekulargewicht: observerd band 148kDa

Gen-ID: 25998

UniProt: Q9P2D0