FZD6 Antikörper (AA 90-170)

Produktnummer ABIN7225244

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch FZD6 in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FZD6 Antikörper (AA 90-170) (ABIN7225244)

Target: FZD6 (Frizzled Family Receptor 6 (FZD6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZD6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FZD6 Antikörper

Bindungsspezifität: AA 90-170

Verwendungszweck: Frizzled-6 Polyclonal Antibody

Spezifität: Frizzled-6 Polyclonal Antibody detects endogenous levels of Frizzled-6 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Frizzled-6 at AA range: 90-170

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu FZD6

Target: FZD6 (Frizzled Family Receptor 6 (FZD6))

Andere Bezeichnung: Frizzled-6

Hintergrund: Rabbit Anti-Frizzled-6 Polyclonal Antibody,FZD6, Frizzled-6, Fz-6, hFz6,FZD6 (frizzled class receptor 6) represents a member of the frizzled gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.,Frizzled-6

Molekulargewicht: observerd band 79kDa

Gen-ID: 8323

UniProt: O60353

Pathways: WNT Signalweg, Tube Formation