DDR1 Antikörper (pTyr513)

Produktnummer ABIN7213284

Der Kaninchen Polyklonal Anti-DDR1 Antikörper wurde für WB, ELISA und IHC (p) validiert. Er ist geeignet, DDR1 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für DDR1 Antikörper (pTyr513) (ABIN7213284)

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-DDR1 Antikörper

Bindungsspezifität: pTyr513

Verwendungszweck: DDR1 (phospho Tyr513) Polyclonal Antibody

Spezifität: Phospho-DDR1 (Y513) Polyclonal Antibody detects endogenous levels of DDR1 protein only when phosphorylated at Y513.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human DDR1 Phospho-Tyr513

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu DDR1

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Andere Bezeichnung: DDR1

Hintergrund: Rabbit Anti-DDR1 (phospho Tyr513) Polyclonal Antibody,DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE, Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2,Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism.Discoidin domain receptor tyrosine kinase 1 encoded by DDR1 belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for DDR1.,Epithelial discoidin domain-containing receptor 1

Molekulargewicht: observerd band 110kDa

Gen-ID: 780

UniProt: Q08345

Pathways: RTK Signalweg, Smooth Muscle Cell Migration