Cyclin E2 Antikörper (pThr392)

Produktnummer ABIN7225830

Dieser Anti-Cyclin E2 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von Cyclin E2 in IF und ELISA. Geeignet für Human und Maus.

Kurzübersicht für Cyclin E2 Antikörper (pThr392) (ABIN7225830)

Target: Cyclin E2 (CCNE2)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin E2 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), ELISA

Produktdetails anti-Cyclin E2 Antikörper

Bindungsspezifität: pThr392

Verwendungszweck: Cyclin E2 (phospho Thr392) Polyclonal Antibody

Spezifität: Phospho-Cyclin E2 (T392) Polyclonal Antibody detects endogenous levels of Cyclin E2 protein only when phosphorylated at T392.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human Cyclin E2 Phospho-Thr392

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu Cyclin E2

Target: Cyclin E2 (CCNE2)

Andere Bezeichnung: Cyclin E2

Hintergrund: Rabbit Anti-Cyclin E2 (phospho Thr392) Polyclonal Antibody,CCNE2, G1/S-specific cyclin-E2,The protein encoded by CCNE2 (cyclin E2)belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of CCNE2 peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.,G1

Gen-ID: 9134

UniProt: O96020

Pathways: Zellzyklus, Mitotic G1-G1/S Phases