Claudin 11 Antikörper (AA 130-210)

Produktnummer ABIN7222878

Dieser Anti-Claudin 11 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von Claudin 11 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für Claudin 11 Antikörper (AA 130-210) (ABIN7222878)

Target: Claudin 11 (CLDN11)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Claudin 11 Antikörper

Bindungsspezifität: AA 130-210

Verwendungszweck: Claudin-11 Polyclonal Antibody

Spezifität: Claudin-11 Polyclonal Antibody detects endogenous levels of Claudin-11 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human Claudin-11 at AA range: 130-210

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu Claudin 11

Target: Claudin 11 (CLDN11)

Andere Bezeichnung: Claudin-11

Hintergrund: Rabbit Anti-Claudin-11 Polyclonal Antibody,CLDN11, OSP, OTM, Claudin-11, Oligodendrocyte-specific protein,CLDN11 encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by CLDN11 is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein claudin 11 is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.,Claudin-11

Molekulargewicht: observerd band 20kDa

Gen-ID: 5010

UniProt: O75508

Pathways: Hepatitis C