AMH Antikörper (AA 380-460)

Produktnummer ABIN7229680

Der Kaninchen Polyklonal anti-AMH Antikörper (ABIN7229680) detektiert spezifisch AMH in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für AMH Antikörper (AA 380-460) (ABIN7229680)

Target: AMH (Anti-Mullerian Hormone (AMH))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AMH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-AMH Antikörper

Bindungsspezifität: AA 380-460

Verwendungszweck: Rabbit Anti-MIS Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of MIS protein

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human MIS protein at AA range: 380-460

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu AMH

Target: AMH (Anti-Mullerian Hormone (AMH))

Andere Bezeichnung: MIS

Hintergrund: Anti-Muellerian hormone, AMH, Muellerian-inhibiting substance, MISAMH encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome.

Molekulargewicht: 61kD

Gen-ID: 268

UniProt: P03971

Pathways: Negative Regulation of Hormone Secretion