SETD7 Antikörper (AA 271-366)

Produktnummer ABIN715541

Der Kaninchen Polyklonal Anti-SETD7-Antikörper wurde für WB, ELISA, FACS, IHC (p), IF (cc), IF (p) und IHC (fro) validiert. Er ist geeignet, SETD7 in Proben von Human zu detektieren.

Kurzübersicht für SETD7 Antikörper (AA 271-366) (ABIN715541)

Target: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SETD7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-SETD7 Antikörper

Bindungsspezifität: AA 271-366

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Histone H4 K4 methyltransferase SETD7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu SETD7

Target: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Andere Bezeichnung: H3-K4-Hmtase Setd7

Hintergrund:

Synonyms: FLJ21193, H3 K4 HMTase, H3-K4-HMTase SETD7, H4 lysine 4 specic, Histone H3 K4 methyltransferase, Histone H3 lysine 4 specic methyltransferase, Histone H3-K4 methyltransferase SETD7, Histone H4 K4 methyltransferase, Histone lysine N methyltransferase, Histone lysine N methyltransferase H3 lysine 4 specic SET7, Histone-lysine N-methyltransferase SETD7, KIAA1717, KMT7, Lysine methyltransferase, Lysine N-methyltransferase 7, OTTHUMP00000164543, OTTHUMP00000220049, SET 7, SET 7/9, SET 9, SET D7, SET domain containing lysine methyltransferase 7, SET domain containing protein 7, SET domain containing protein 8, SET domain-containing protein 7, SET7, SET7/9, SET9, Setd7, SETD7_HUMAN.

Background: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.

Gen-ID: 80854

UniProt: Q8WTS6