SETD7 Antikörper

Produktnummer ABIN7270261

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch SETD7 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SETD7 Antikörper (ABIN7270261)

Target: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SETD7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SETD7 Antikörper

Verwendungszweck: SETD7 Rabbit mAb

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human SETD7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SETD7

Target: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Andere Bezeichnung: SETD7

Hintergrund: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.,KMT7, SET7, SET7/9, SET9,Epigenetic writers and erasers of core Histones,Epigenetic writers and erasers of core Histones_Methylation,Epigenetics & Nuclear Signaling,SETD7

Molekulargewicht: 41kDa

Gen-ID: 80854

UniProt: Q8WTS6