MLH1 Antikörper (AA 381-483)
Kurzübersicht für MLH1 Antikörper (AA 381-483) (ABIN7193525)
Target
Alle MLH1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 381-483
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Verwendungszweck
- MLH1 Antibody
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Aufreinigung
- Purified antibody
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Immunogen
- Purified recombinant fragment of human MLH1 (AA: 381-483) expressed in E. Coli.
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Isotyp
- IgG2b
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anti-MutL Homolog 1 (MLH1) (AA 381-483) antibody
MLH1 Reaktivität: Human WB, ELISA, IHC, FACS Wirt: Maus Monoclonal 7A7C8 unconjugated
anti-MutL Homolog 1 (MLH1) (AA 1-756) antibodyMLH1 Reaktivität: Human WB, ELISA, IF, IHC (p), PLA Wirt: Maus Monoclonal M1 unconjugated
anti-MutL Homolog 1 (MLH1) (AA 350-519) antibodyMLH1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (AA 381-483) antibodyMLH1 Reaktivität: Human, Affe WB, ELISA, IHC, ICC Wirt: Maus Monoclonal 4C9C7 unconjugated
anti-MutL Homolog 1 (MLH1) antibodyMLH1 Reaktivität: Human, Maus WB, IP Wirt: Maus Monoclonal G168-728 unconjugated
anti-MutL Homolog 1 (MLH1) antibodyMLH1 Reaktivität: Human WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (Internal Region) antibodyMLH1 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (Internal Region) antibodyMLH1 Reaktivität: Human, Maus, Ratte WB, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (AA 501-600) antibodyMLH1 Reaktivität: Human ELISA, IHC (p), IF (p), IF (cc), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (AA 452-480) antibodyMLH1 Reaktivität: Human WB, FACS Wirt: Kaninchen Polyclonal RB18813 unconjugated
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Applikationshinweise
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- MLH1 (MutL Homolog 1 (MLH1))
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Andere Bezeichnung
- MLH1
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Hintergrund
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The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
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Molekulargewicht
- 84.6 kDa
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Gen-ID
- 4292
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UniProt
- P40692
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Pathways
- DNA Reparatur, Production of Molecular Mediator of Immune Response
Target
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