MLL/KMT2A Antikörper (AA 801-956)

Produktnummer ABIN7193384

Der Maus Monoklonal Anti-MLL/KMT2A-Antikörper wurde für ELISA validiert. Er ist geeignet, MLL/KMT2A in Proben von Human zu detektieren.

Kurzübersicht für MLL/KMT2A Antikörper (AA 801-956) (ABIN7193384)

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MLL/KMT2A Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 4A5A12

Produktdetails anti-MLL/KMT2A Antikörper

Bindungsspezifität: AA 801-956

Verwendungszweck: KMT2A Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human KMT2A (AA: 801-956) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu MLL/KMT2A

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Andere Bezeichnung: KMT2A

Hintergrund:

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

Molekulargewicht: 431.7 kDa

Gen-ID: 4297

UniProt: Q03164

Pathways: Warburg Effekt