PRPS1 Antikörper

Produktnummer ABIN7192028

Der Kaninchen Polyklonal Anti-PRPS1-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, PRPS1 in Proben von Human zu detektieren.

Kurzübersicht für PRPS1 Antikörper (ABIN7192028)

Target: PRPS1 (phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRPS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-PRPS1 Antikörper

Verwendungszweck: PRPS1/PRPS2/PRPS1L1 Antibody

Kreuzreaktivität: Maus

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of Human PRPS1/2/1L1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:  pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PRPS1

Target: PRPS1 (phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1))

Andere Bezeichnung: PRPS1

Hintergrund:

Background: PRPS (phosphoribosyl pyrophosphate synthetase) proteins catalyze the synthesis of phosphoribosyl pyrophosphate (PRPP). Three human PRPS isoforms exist and are encoded by three different genes. PRPS1 and PRPS2 (also known as PRS1 and PRS2, respectively) are ubiquitously expressed, while PRPS3 (also known as PRPS1L1) is specific to the testis. PRPP is an important substrate synthesized from MgATP and ribose-5-phosphate in a reaction that requires inorganic phosphate and magnesium as a cofactor. PRPP is essential in the synthesis of nearly all nucleotides, implying that PRPS1/2 play an important role in nucleotide biosynthesis and purine metabolism. A mutation in the gene encoding PRPS1 may result in PRPS superactivity, a disease characterized by gout and the overproduction of purine nucleotides, uric acid and PRPP. PRPS1 mutations can also lead to a reduction in PRPS1 activity resulting in ARTS syndrome or CMTX5 (Charcot-Marie-Tooth disease X-linked recessive type 5).

Aliases: phosphoribosyl pyrophosphate synthetase 1/2/1-like 1

UniProt: P60891, P11908, P21108

Pathways: Ribonucleoside Biosynthetic Process