BNIP3L/NIX Antikörper (AA 51-150) (Biotin)
Kurzübersicht für BNIP3L/NIX Antikörper (AA 51-150) (Biotin) (ABIN714913)
Target
Alle BNIP3L/NIX (BNIP3L) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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    - 
                                            Bindungsspezifität
- AA 51-150
- 
                                            Kreuzreaktivität
- Maus
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                                            Homologie
- Human,Rat,Cow,Pig,Horse,Rabbit
- 
                                            Aufreinigung
- Purified by Protein A.
- 
                                            Immunogen
- KLH conjugated synthetic peptide derived from human BNIP3L
- 
                                            Isotyp
- IgG
 
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- 
    
- 
    - 
                                            Applikationshinweise
- 
                        IHC-P 1:200-400
 IHC-F 1:100-500
- 
                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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    - 
                                            Format
- Liquid
- 
                                            Konzentration
- 1 μg/μL
- 
                                            Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 
                                            Konservierungsmittel
- ProClin
- 
                                            Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 
                                            Lagerung
- -20 °C
- 
                                            Informationen zur Lagerung
- Store at -20°C for 12 months.
- 
                                            Haltbarkeit
- 12 months
 
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- 
    - BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))
- 
                                            Andere Bezeichnung
- BNIP3L
- 
                                            Hintergrund
- 
                        Synonyms: NIX, BNIP3a, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like, Adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, NIP3-like protein X, NIP3L, BNIP3L, BNIP3H Background: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. 
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                                            Gen-ID
- 665
- 
                                            UniProt
- O60238
- 
                                            Pathways
- Autophagie
 Target
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