CHAF1A Antikörper

Produktnummer ABIN7183230

Der Kaninchen-Polyklonal Anti-CHAF1A-Antikörper wurde für WB, ELISA, IHC und IF validiert. Er ist geeignet zum Nachweis von CHAF1A in Proben aus Human. }

Kurzübersicht für CHAF1A Antikörper (ABIN7183230)

Target: CHAF1A (Chromatin Assembly Factor 1, Subunit A (p150) (CHAF1A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHAF1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-CHAF1A Antikörper

Verwendungszweck: CHAF1A Antibody

Kreuzreaktivität: Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human CAF1A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CHAF1A

Target: CHAF1A (Chromatin Assembly Factor 1, Subunit A (p150) (CHAF1A))

Andere Bezeichnung: CHAF1A

Hintergrund:

Background: Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA, histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci By similarity. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Dong H., Gene 264:187-196(2001) [PubMed: 11250073].
Grimwood J., Nature 428:529-535(2004) [PubMed: 15057824].
Kaufman P.D., Cell 81:1105-1114(1995) [PubMed: 7600578].

Aliases: CAF 1 antibody, CAF 1 subunit A antibody, CAF antibody, CAF I 150 kDa subunit antibody, CAF I p150 antibody, CAF-1 subunit A antibody, CAF-I 150 kDa subunit antibody, CAF-I p150 antibody, CAF1 antibody, CAF1A_HUMAN antibody, CAF1B antibody, CAF1P150 antibody, CHAF1A antibody, Chromatin assembly factor 1 subunit A antibody, Chromatin Assembly Factor 1 Subunit A p150 antibody, Chromatin assembly factor I (150 kDa) antibody, Chromatin assembly factor I 150 kDa antibody, Chromatin assembly factor I p150 subunit antibody, DCAF1 antibody, hp150 antibody, MGC71229 antibody, P150 antibody

UniProt: Q13111