Neuregulin 1 Antikörper (Isoform 10)

Produktnummer ABIN7182178

Dieses Anti-Neuregulin 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Neuregulin 1 in WB, IHC und ELISA. Geeignet für Human.

Kurzübersicht für Neuregulin 1 Antikörper (Isoform 10) (ABIN7182178)

Target: Neuregulin 1 (NRG1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuregulin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Neuregulin 1 Antikörper

Bindungsspezifität: Isoform 10

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Human NRG1 isoform-10.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Neuregulin 1

Target: Neuregulin 1 (NRG1)

Andere Bezeichnung: NRG1

Hintergrund:

Background: The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Xiao-Feng Le, Cancer Res., Jul 2000, 60: 3522 - 3531.
Samuel D. H. Chan, J. Biol. Chem., Sep 1995, 270: 22608.
Daniel C. Gamett, J. Biol. Chem., Aug 1995, 270: 19022.
Mohammed Rahmatullah, Mol. Cell. Biol., Nov 1998, 18: 6245 - 6252.

Aliases: Pro-neuregulin-1, membrane-bound isoform, Pro-NRG1, NRG1, GGF

UniProt: Q15491

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation