FER Antikörper (C-Term)

Produktnummer ABIN7180174

Dieses Anti-FER-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FER in WB und ELISA. Geeignet für Human.

Kurzübersicht für FER Antikörper (C-Term) (ABIN7180174)

Target: FER (FER Tyrosine Kinase (FER))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FER Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-FER Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human FER.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FER

Target: FER (FER Tyrosine Kinase (FER))

Andere Bezeichnung: FER

Hintergrund:

Background:

Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.

Hao Q.-L., Mol. Cell. Biol. 9:1587-1593(1989).
Lee S.-T., Oncogene 8:3403-3410(1993).
Krolewski J.J., Oncogene 5:277-282(1990).

Aliases: c FER antibody, Feline encephalitis virus related kinase FER antibody, Fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) antibody, Fer (fps/fes related) tyrosine kinase antibody, FER antibody, FER_HUMAN antibody, FerT antibody, Fujinami poultry sarcoma/Feline sarcoma related protein Fer antibody, p94 FER antibody, p94-FER antibody, Pe1Fe10 antibody, Pe1Fe13 antibody, Pe1Fe3 antibody, Pe1Fe6 antibody, Phosphoprotein NCP94 antibody, PPP1R74 antibody, Protein phosphatase 1 regulatory subunit 74 antibody, Proto oncogene tyrosine protein kinase FER antibody, Proto-oncogene c-Fer antibody, TYK3 antibody, Tyrosine kinase 3 antibody, Tyrosine-protein kinase Fer antibody

UniProt: P16591