FAS Antikörper (C-Term)

Produktnummer ABIN7180172

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FAS in WB, IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FAS Antikörper (C-Term) (ABIN7180172)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-FAS Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Human

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human Fas.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Andere Bezeichnung: FAS

Hintergrund:

Background: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Michael J. Pinkoski, Am JPhysiol Gastrointest Liver Physiol, Mar 2000, 278: 354.
Morgan Jenkins, J. Immunol., Aug 1999, 163: 1195.
Nicholas Mitsiades, J Natl Cancer Inst, Oct 1999, 91: 1678 - 1684.
JOS? E. CARDIER, FASEB J, Nov 1999, 13: 1950.

Aliases: ALPS 1A antibody, ALPS1A antibody, APO 1 antibody, Apo 1 antigen antibody, APO 1 cell surface antigen antibody, Apo-1 antigen antibody, APO1 antibody, Apo1 antigen antibody, APO1 cell surface antigen antibody, Apoptosis antigen 1 antibody, Apoptosis mediating surface antigen FAS antibody, Apoptosis-mediating surface antigen FAS antibody, APT 1 antibody, APT1 antibody, CD 95 antibody, CD 95 antigen antibody, CD95 antibody, CD95 antigen antibody, Delta Fas antibody, Delta Fas/APO 1/CD95 antibody, Delta Fas/APO1/CD95 antibody, Fas (TNF receptor superfamily, member 6) antibody, FAS 1 antibody, FAS 827dupA antibody, Fas AMA antibody, Fas antibody, FAS Antigen antibody, Fas cell surface death receptor antibody, FAS1 antibody, FASLG receptor antibody, FASTM antibody, sFAS antibody, Surface antigen APO1 antibody, TNF receptor superfamily, member 6 antibody, TNFRSF 6 antibody, TNFRSF6 antibody, TNR6_HUMAN antibody, Tumor necrosis factor receptor superfamily member 6 antibody

UniProt: P25445

Pathways: p53 Signalweg, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity