EPH Receptor B2 Antikörper (C-Term)

Produktnummer ABIN7180167

Produktdetails anti-EPH Receptor B2 Antikörper

Target: EPH Receptor B2 (EPHB2)

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor B2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human EPHB2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EPH Receptor B2

Target: EPH Receptor B2 (EPHB2)

Andere Bezeichnung: EPHB2 (EPHB2 Produkte)

Hintergrund:

Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. Beside axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

Kiyokawa E., Cancer Res. 54:3645-3650(1994).
Ikegaki N., Hum. Mol. Genet. 4:2033-2045(1995).
Tang X.X., Oncogene 17:521-526(1998).

Aliases: cek5 antibody, Developmentally regulated EPH related tyrosine kinase antibody, DRT antibody, EK5 antibody, ELK related protein tyrosine kinase antibody, Eph receptor B2 antibody, EPH tyrosine kinase 3 antibody, EPH-like kinase 5 antibody, EPHB2 antibody, EPHB2_HUMAN antibody, Ephrin type B receptor 2 antibody, Ephrin type-B receptor 2 antibody, EPHT 3 antibody, ERK antibody, ETECK antibody, hEK5 antibody, Nuk antibody, Prkm 5 antibody, Receptor protein tyrosine kinase HEK 5 antibody, Renal carcinoma antigen NY-REN-47 antibody, Sek 3 antibody, Tyro 5 antibody, Tyrosine protein kinase receptor CEK 5 antibody, Tyrosine protein kinase receptor EPH 3 antibody, Tyrosine protein kinase receptor QEK 5 antibody, Tyrosine-protein kinase receptor EPH-3 antibody, Tyrosine-protein kinase TYRO5 antibody

UniProt: P29323

Pathways: RTK Signalweg, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteine