SMAD2 Antikörper (Thr220)

Produktnummer ABIN7180083

Der Kaninchen Polyklonal Anti-SMAD2-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, SMAD2 in Proben von Human zu detektieren.

Kurzübersicht für SMAD2 Antikörper (Thr220) (ABIN7180083)

Target: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-SMAD2 Antikörper

Bindungsspezifität: Thr220

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human Smad2 around the phosphorylation site of threonine 220 (P-E-T(p)-P-P).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SMAD2

Target: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Andere Bezeichnung: SMAD2

Hintergrund:

Background: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Riggins G.J., Nat. Genet. 13:347-349(1996).
Zhang Y., Nature 383:168-172(1996).
Eppert K., Cell 86:543-552(1996).

Aliases: Drosophila, homolog of, MADR2 antibody, hMAD-2 antibody, HsMAD2 antibody, JV18 antibody, JV18-1 antibody, JV181 antibody, MAD antibody, MAD homolog 2 antibody, MAD Related Protein 2 antibody, Mad-related protein 2 antibody, MADH2 antibody, MADR2 antibody, MGC22139 antibody, MGC34440 antibody, Mother against DPP homolog 2 antibody, Mothers against decapentaplegic homolog 2 antibody, Mothers against decapentaplegic, Drosophila, homolog of, 2 antibody, Mothers against DPP homolog 2 antibody, OTTHUMP00000163489 antibody, Sma and Mad related protein 2 antibody, Sma- and Mad-related protein 2 MAD antibody, SMAD 2 antibody, SMAD family member 2 antibody, SMAD, mothers against DPP homolog 2 antibody, SMAD2 antibody, SMAD2_HUMAN antibody

UniProt: Q15796

Pathways: Zellzyklus, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus