BCAR1 Antikörper (Tyr410)

Produktnummer ABIN7180057

Dieses Anti-BCAR1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BCAR1 in WB, IHC und ELISA. Geeignet für Human.

Kurzübersicht für BCAR1 Antikörper (Tyr410) (ABIN7180057)

Target: BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-BCAR1 Antikörper

Bindungsspezifität: Tyr410

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human p130 Cas around the phosphorylation site of tyrosine 410 (G-V-T-A-V).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BCAR1

Target: BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))

Andere Bezeichnung: BCAR1

Hintergrund:

Background: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

Katarzyna Modzelewska, J. Biol. Chem., Dec 2006, 281: 37527 - 37535.
Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006, 291: H2857 - H2863.
Sangkil Nam, Cancer Res., Oct 2005, 65: 9185 - 9189.
Norikazu Yamana, Mol. Cell. Biol., Sep 2006, 26: 6844 - 6

Aliases: BCAR 1 antibody, Bcar1 antibody, BCAR1_HUMAN antibody, Breast cancer anti estrogen resistance 1 antibody, Breast cancer anti estrogen resistance 1 protein antibody, Breast cancer anti-estrogen resistance protein 1 antibody, CAS antibody, Cas scaffolding protein family member 1 antibody, CAS1 antibody, Cass1 antibody, Crk associated substrate antibody, Crk associated substrate p130Cas antibody, CRK-associated substrate antibody, CRKAS antibody, FLJ12176 antibody, FLJ45059 antibody, p130cas antibody

UniProt: P56945

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling