MITF Antikörper (Ser73, Ser180)

Produktnummer ABIN7180048

Dieses Anti-MITF-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MITF in WB, IHC, IF und ELISA. Geeignet für Human.

Kurzübersicht für MITF Antikörper (Ser73, Ser180) (ABIN7180048)

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MITF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Produktdetails anti-MITF Antikörper

Bindungsspezifität: Ser73, Ser180

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human MITF around the phosphorylation site of serine 180/73 (P-N-S(p)-P-M).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MITF

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Andere Bezeichnung: MITF

Hintergrund:

Background: Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

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Aliases: BHLHE32 antibody, bHLHe32 antibody, Class E basic helix-loop-helix protein 32 antibody, CMM8 antibody, Homolog of mouse microphthalmia antibody, Mi antibody, Microphthalmia associated transcription factor antibody, Microphthalmia, mouse, homolog of antibody, Microphthalmia-associated transcription factor antibody, MITF antibody, MITF_HUMAN antibody, mitfa antibody, nacre antibody, WS2 antibody, WS2A antibody, z3A.1 antibody

UniProt: O75030

Pathways: Chromatin Binding