VCP Antikörper (AA 704-806) (Biotin)

Produktnummer ABIN7179883

Dieses Anti-VCP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von VCP in ELISA. Geeignet für Zebrafisch (Danio rerio).

Kurzübersicht für VCP Antikörper (AA 704-806) (Biotin) (ABIN7179883)

Target: VCP (Valosin Containing Protein (VCP))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VCP Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-VCP Antikörper (Biotin)

Bindungsspezifität: AA 704-806

Kreuzreaktivität: Zebrafisch (Danio rerio)

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Zebrafish Transitional endoplasmic reticulum ATPase protein (704-806AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu VCP

Target: VCP (Valosin Containing Protein (VCP))

Andere Bezeichnung: vcp

Hintergrund:

Background: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites (By similarity). Enhances cell cycle progression and inhibits apoptosis at low temperatures (PubMed:12914916). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (By similarity). Acts as a negative regulator of type I interferon production by promoting ubiquitination of ddx58/rig-i (By similarity). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (By similarity).

Aliases: vcp antibody, cdc48 antibody, si:ch211-113n10.2Transitional endoplasmic reticulum ATPase antibody, TER ATPase antibody, EC 3.6.4.6 antibody, Protein CDC48 antibody, Valosin-containing protein antibody, VCP antibody

UniProt: Q7ZU99

Pathways: ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway