Notch1 Antikörper (AA 21-338) (HRP)

Produktnummer ABIN7179801

Der Kaninchen Polyklonal Anti-Notch1-Antikörper wurde für ELISA validiert. Er ist geeignet, Notch1 in Proben von Zebrafisch (Danio rerio) zu detektieren.

Kurzübersicht für Notch1 Antikörper (AA 21-338) (HRP) (ABIN7179801)

Target: Notch1 (NOTCH1) (Notch 1 (NOTCH1))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Notch1 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-Notch1 Antikörper (HRP)

Bindungsspezifität: AA 21-338

Kreuzreaktivität: Zebrafisch (Danio rerio)

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Zebrafish Neurogenic locus notch homolog protein 1 protein (21-338AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Notch1

Target: Notch1 (NOTCH1) (Notch 1 (NOTCH1))

Andere Bezeichnung: notch1a

Hintergrund:

Background: Functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).

Aliases: notch1a antibody, notch antibody, Neurogenic locus notch homolog protein 1 antibody, Notch 1) [Cleaved into: Notch 1 extracellular truncation antibody, NEXT), Notch 1 intracellular domain antibody, NICD)] antibody

UniProt: P46530

Pathways: Notch Signalweg, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development