SOCS3 Antikörper (AA 1-225)

Produktnummer ABIN7179081

Der Kaninchen Polyklonal Anti-SOCS3-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, SOCS3 in Proben von Ratte zu detektieren.

Kurzübersicht für SOCS3 Antikörper (AA 1-225) (ABIN7179081)

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SOCS3 Antikörper

Bindungsspezifität: AA 1-225

Kreuzreaktivität: Human, Ratte

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Rat Suppressor of cytokine signaling 3 protein (1-225AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Andere Bezeichnung: Socs3

Hintergrund:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Aliases: Socs3 antibody, Cish3Suppressor of cytokine signaling 3 antibody, SOCS-3 antibody, Cytokine-inducible SH2 protein 3 antibody

UniProt: O88583

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus, Hepatitis C