TXNIP Antikörper (AA 1-397) (HRP)

Produktnummer ABIN7177898

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TXNIP in ELISA. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für TXNIP Antikörper (AA 1-397) (HRP) (ABIN7177898)

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TXNIP Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-TXNIP Antikörper (HRP)

Bindungsspezifität: AA 1-397

Kreuzreaktivität: Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Mouse Thioredoxin-interacting protein (1-397AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TXNIP

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Andere Bezeichnung: Txnip

Hintergrund:

Background: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.

Aliases: Txnip antibody, Vdup1 antibody, Thioredoxin-interacting protein antibody, Vitamin D3 up-regulated protein 1 antibody

UniProt: Q8BG60

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome