YTHDC1 Antikörper (AA 89-153) (FITC)

Produktnummer ABIN7175952

Der Kaninchen Polyklonal Anti-YTHDC1-Antikörper wurde für validiert. Er ist geeignet, YTHDC1 in Proben von Human zu detektieren.

Kurzübersicht für YTHDC1 Antikörper (AA 89-153) (FITC) (ABIN7175952)

Target: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YTHDC1 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-YTHDC1 Antikörper (FITC)

Bindungsspezifität: AA 89-153

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human YTH domain-containing protein 1 protein (89-153AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu YTHDC1

Target: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Andere Bezeichnung: YTHDC1

Hintergrund:

Background: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602).

Aliases: YTHDC1 antibody, KIAA1966 antibody, YT521 antibody, YTH domain-containing protein 1 antibody, Splicing factor YT521 antibody, YT521-B antibody

UniProt: Q96MU7