Villin 1 Antikörper (AA 1-350)

Produktnummer ABIN7175510

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Villin 1 in IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Villin 1 Antikörper (AA 1-350) (ABIN7175510)

Target: Villin 1 (VIL1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Villin 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-Villin 1 Antikörper

Bindungsspezifität: AA 1-350

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Villin-1 protein (1-350AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Villin 1

Target: Villin 1 (VIL1)

Andere Bezeichnung: VIL1

Hintergrund:

Background: Epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA), binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.

Aliases: D2S1471 antibody, OTTHUMP00000164145 antibody, VIL antibody, VIL1 antibody, VILI_HUMAN antibody, Villin 1 antibody, Villin-1 antibody, Villin1 antibody

UniProt: P09327

Pathways: EGFR Signaling Pathway, Regulation of Actin Filament Polymerization