VPS4A Antikörper (AA 1-120)

Produktnummer ABIN7175319

Der Kaninchen Polyklonal Anti-VPS4A-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, VPS4A in Proben von Human zu detektieren.

Kurzübersicht für VPS4A Antikörper (AA 1-120) (ABIN7175319)

Target: VPS4A (Vacuolar Protein Sorting-Associated Protein 4A (VPS4A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS4A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-VPS4A Antikörper

Bindungsspezifität: AA 1-120

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Vacuolar protein sorting-associated protein 4A protein (1-120AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu VPS4A

Target: VPS4A (Vacuolar Protein Sorting-Associated Protein 4A (VPS4A))

Andere Bezeichnung: VPS4A

Hintergrund:

Background: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Aliases: hVPS4 antibody, Protein SKD2 antibody, SKD1 antibody, SKD1 homolog antibody, SKD1A antibody, SKD2 antibody, Vacuolar protein sorting 4 homolog A antibody, Vacuolar protein sorting 4, yeast, homolog of, A antibody, Vacuolar protein sorting factor 4A antibody, Vacuolar protein sorting-associated protein 4A antibody, vacuolar sorting protein 4 antibody, VPS4 antibody, VPS4-1 antibody, Vps4a antibody, VPS4A_HUMAN antibody

UniProt: Q9UN37

Pathways: Microtubule Dynamics, CXCR4-mediated Signaling Events