VPS26B Antikörper (AA 1-336) (Biotin)

Produktnummer ABIN7354702

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch VPS26B in ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für VPS26B Antikörper (AA 1-336) (Biotin) (ABIN7354702)

Target: VPS26B (Vacuolar Protein Sorting 26 Homolog B (VPS26B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS26B Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-VPS26B Antikörper (Biotin)

Bindungsspezifität: AA 1-336

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Vacuolar protein sorting-associated protein 26B protein (1-336AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu VPS26B

Target: VPS26B (Vacuolar Protein Sorting 26 Homolog B (VPS26B))

Andere Bezeichnung: VPS26B

Hintergrund:

Background: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).

Aliases: Pep8b antibody, Vacuolar protein sorting 26 homolog B (S. pombe) antibody, Vacuolar protein sorting 26 homolog B (yeast) antibody, Vacuolar protein sorting-associated protein 26B antibody, Vesicle protein sorting 26B antibody, VP26B_HUMAN antibody, VPS26B antibody

UniProt: Q4G0F5

Pathways: Cellular Glucan Metabolic Process