ATG3 Antikörper (AA 1-314) (HRP)

Produktnummer ABIN7174570

Dieses Anti-ATG3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ATG3 in ELISA. Geeignet für Human.

Kurzübersicht für ATG3 Antikörper (AA 1-314) (HRP) (ABIN7174570)

Target: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG3 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-ATG3 Antikörper (HRP)

Bindungsspezifität: AA 1-314

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-like-conjugating enzyme ATG3 protein (1-314AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ATG3

Target: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Andere Bezeichnung: ATG3

Hintergrund:

Background: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Aliases: 2610016C12Rik antibody, Apg 3 antibody, APG3 antibody, APG3 autophagy 3 like antibody, APG3 like antibody, APG3, S. cerevisiae, homolog of antibody, APG3-like antibody, APG3L antibody, Apg3p antibody, ATG 3 antibody, ATG3 antibody, ATG3 autophagy related 3 homolog antibody, ATG3 autophagy related 3 homolog (S. cerevisiae) antibody, ATG3_HUMAN antibody, Autophagy 3, S. cerevisiae, homolog of antibody, Autophagy Apg3p/Aut1p like antibody, autophagy related 3 antibody, Autophagy related protein 3 antibody, Autophagy-related protein 3 antibody, DKFZp564M1178 antibody, FLJ22125 antibody, hApg3 antibody, MGC15201 antibody, OTTHUMP00000214547 antibody, OTTHUMP00000214548 antibody, PC3 96 antibody, Protein PC3-96 antibody, Ubiquitin-like-conjugating enzyme ATG3 antibody

UniProt: Q9NT62

Pathways: Autophagie