UBE2V1 Antikörper (AA 2-147)

Produktnummer ABIN7174489

Produktdetails anti-UBE2V1 Antikörper

Target: UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))

Bindungsspezifität: AA 2-147

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2V1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-conjugating enzyme E2 variant 1 protein (2-147AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu UBE2V1

Target: UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))

Andere Bezeichnung: UBE2V1 (UBE2V1 Produkte)

Synonyme: CIR1 antikoerper, CROC-1 antikoerper, CROC1 antikoerper, UBE2V antikoerper, UEV-1 antikoerper, UEV1 antikoerper, UEV1A antikoerper, 0610011J09Rik antikoerper, AI256840 antikoerper, D7Bwg1382e antikoerper, CROC-1B antikoerper, ubiquitin conjugating enzyme E2 V1 antikoerper, ubiquitin-conjugating enzyme E2 variant 1 antikoerper, UBE2V1 antikoerper, ube2v1 antikoerper, Ube2v1 antikoerper

Hintergrund:

Background: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate \'Lys-63\'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.

Aliases: CIR1 antibody, CROC-1 antibody, CROC1 antibody, CROC1A antibody, TRAF6-regulated IKK activator 1 beta Uev1A antibody, UB2V1_HUMAN antibody, UBE2V 1 antibody, UBE2V antibody, UBE2V1 antibody, Ubiquitin conjugating enzyme E2 variant 1 antibody, Ubiquitin-conjugating enzyme E2 variant 1 antibody, UEV-1 antibody, UEV1 antibody

UniProt: Q13404

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades