USP8 Antikörper (C-Term)

Produktnummer ABIN7174360

Dieses Anti-USP8-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von USP8 in WB, IHC und ELISA. Geeignet für Human.

Kurzübersicht für USP8 Antikörper (C-Term) (ABIN7174360)

Target: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-USP8 Antikörper

Bindungsspezifität: AA 1-270, C-Term

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 8 protein (1-270AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu USP8

Target: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Andere Bezeichnung: USP8

Hintergrund:

Background: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both \\\'Lys-48\\\' an \\\'Lys-63\\\'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.

Aliases: Deubiquitinating enzyme 8 antibody, FLJ34456 antibody, hUBPy antibody, HumORF8 antibody, KIAA0055 antibody, MGC129718 antibody, SPG59 antibody, Ubiquitin carboxyl-terminal hydrolase 8 antibody, Ubiquitin isopeptidase Y antibody, ubiquitin specific peptidase 8 antibody, Ubiquitin thioesterase 8 antibody, Ubiquitin-specific-processing protease 8 antibody, UBP8_HUMAN antibody, UBPY antibody, Usp8 antibody

UniProt: P40818