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USP8 Antikörper (C-Term)

USP8 Reaktivität: Human WB Wirt: Maus Monoclonal 460CT35-1-6 unconjugated
Produktnummer ABIN1536612
  • Target Alle USP8 Antikörper anzeigen
    USP8 (Ubiquitin Specific Peptidase 8 (USP8))
    Bindungsspezifität
    • 10
    • 9
    • 7
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, C-Term
    Reaktivität
    • 46
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 44
    • 1
    • 1
    Maus
    Klonalität
    • 45
    • 1
    Monoklonal
    Konjugat
    • 26
    • 4
    • 4
    • 4
    • 4
    • 4
    Dieser USP8 Antikörper ist unkonjugiert
    Applikation
    • 42
    • 26
    • 18
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    M
    Aufreinigung
    Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
    Immunogen
    This USP8 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the C-terminal region of human USP8.
    Klon
    460CT35-1-6
    Isotyp
    IgG1
    Top Product
    Discover our top product USP8 Primärantikörper
  • Applikationshinweise
    WB: 1:500~4000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    USP8 Antibody (C-term C1072)(Ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Haltbarkeit
    6 months
  • Target
    USP8 (Ubiquitin Specific Peptidase 8 (USP8))
    Andere Bezeichnung
    USP8 (USP8 Produkte)
    Synonyme
    HumORF8 antikoerper, UBPY antikoerper, AI574262 antikoerper, AW557536 antikoerper, Ubpy antikoerper, mKIAA0055 antikoerper, ubiquitin carboxyl-terminal hydrolase 8 antikoerper, ubiquitin specific peptidase 8 antikoerper, LOC9310109 antikoerper, MGYG_00369 antikoerper, USP8 antikoerper, Usp8 antikoerper
    Hintergrund
    Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.
    Molekulargewicht
    127523
    Gen-ID
    9101
    NCBI Accession
    NP_001122082, NP_001122083, NP_005145
    UniProt
    P40818
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