USP8 Antikörper (C-Term)

Produktnummer ABIN1536612

Der Maus Monoklonal anti-USP8 Antikörper (Klon 460CT35-1-6) (ABIN1536612) detektiert spezifisch USP8 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für USP8 Antikörper (C-Term) (ABIN1536612)

Target: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser USP8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 460CT35-1-6

Produktdetails anti-USP8 Antikörper

Bindungsspezifität: AA 1-30, C-Term

Homologie: M

Aufreinigung: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This USP8 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the C-terminal region of human USP8.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500~4000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: USP8 Antibody (C-term C1072)(Ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu USP8

Target: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Andere Bezeichnung: USP8

Hintergrund: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.

Molekulargewicht: 127523

Gen-ID: 9101

NCBI Accession: NP_001122082, NP_001122083, NP_005145

UniProt: P40818