USP2 Antikörper (C-Term) (Biotin)

Produktnummer ABIN7174285

Dieses Anti-USP2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von USP2 in ELISA. Geeignet für Human.

Kurzübersicht für USP2 Antikörper (C-Term) (Biotin) (ABIN7174285)

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP2 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-USP2 Antikörper (Biotin)

Bindungsspezifität: AA 258-417, C-Term

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 20 protein (258-417AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu USP2

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Andere Bezeichnung: USP2

Hintergrund:

Background: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both \'Lys-48\'- and \'Lys-63\'-linked polyubiquitin chains.

Aliases: Deubiquitinating enzyme 20 antibody, hVDU2 antibody, KIAA1003 antibody, LSFR 3A antibody, LSFR3A antibody, pVHL interacting deubiquitinating enzyme 2 antibody, Ubiquitin carboxyl terminal hydrolase 20 antibody, Ubiquitin carboxyl-terminal hydrolase 20 antibody, ubiquitin specific peptidase 20 antibody, Ubiquitin specific processing protease 20 antibody, Ubiquitin specific protease 20 antibody, Ubiquitin thioesterase 20 antibody, Ubiquitin thiolesterase 20 antibody, Ubiquitin-specific-processing protease 20 antibody, UBP20_HUMAN antibody, USP 20 antibody, USP20 antibody, VDU 2 antibody, VDU2 antibody, VHL interacting deubiquitinating enzyme 2 antibody, VHL-interacting deubiquitinating enzyme 2 antibody

UniProt: Q9Y2K6