USP2 Antikörper (AA 245-275)

Produktnummer ABIN1882149

Zitiert in 3+ Publikationen. Der Kaninchen Polyklonal anti-USP2 Antikörper (Klon RB4416) (ABIN1882149) detektiert spezifisch USP2. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für USP2 Antikörper (AA 245-275) (ABIN1882149)

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP2 Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Klon: RB4416

Produktdetails anti-USP2 Antikörper

Bindungsspezifität: AA 245-275

Homologie: B, M, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This USP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-275 amino acids from human USP2.

Isotyp: Ig Fraction

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-USP2 Antikörper (ABIN1882149)

Tong, Buelow, Guha, Rausch, Yin: "USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25280-91, (2012) (PubMed).

Haimerl, Erhardt, Sass, Tiegs: "Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival." in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 495-504, (2008) (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

Details zu USP2

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Andere Bezeichnung: USP2

Hintergrund: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Molekulargewicht: 68072

NCBI Accession: NP_001230688, NP_004196, NP_741994

UniProt: O75604