Ubiquilin 2 Antikörper (AA 473-542) (Biotin)

Produktnummer ABIN7174229

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Ubiquilin 2 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Ubiquilin 2 Antikörper (AA 473-542) (Biotin) (ABIN7174229)

Target: Ubiquilin 2 (UBQLN2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ubiquilin 2 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-Ubiquilin 2 Antikörper (Biotin)

Bindungsspezifität: AA 473-542

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquilin-2 protein (473-542AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Ubiquilin 2

Target: Ubiquilin 2 (UBQLN2)

Andere Bezeichnung: UBQLN2

Hintergrund:

Background: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation, required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).

Aliases: UBQLN2 antibody, N4BP4 antibody, PLIC2 antibody, HRIHFB2157Ubiquilin-2 antibody, Chap1 antibody, DSK2 homolog antibody, Protein linking IAP with cytoskeleton 2 antibody, PLIC-2 antibody, hPLIC-2 antibody, Ubiquitin-like product Chap1/Dsk2 antibody

UniProt: Q9UHD9