TYRO3 Antikörper (AA 728-873) (HRP)

Produktnummer ABIN7174055

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TYRO3 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TYRO3 Antikörper (AA 728-873) (HRP) (ABIN7174055)

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TYRO3 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-TYRO3 Antikörper (HRP)

Bindungsspezifität: AA 728-873

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Tyrosine-protein kinase receptor TYRO3 protein (728-873AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TYRO3

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Andere Bezeichnung: TYRO3

Hintergrund:

Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Aliases: Brt antibody, BYK antibody, DTK antibody, Etk-2 antibody, protein tyrosine kinase 3 antibody, Rek antibody, RSE antibody, SKY antibody, Tif antibody, tyro3 antibody, TYRO3 protein tyrosine kinase antibody, TYRO3_HUMAN antibody, Tyrosine-protein kinase byk antibody, Tyrosine-protein kinase DTK antibody, Tyrosine-protein kinase receptor TYRO3 antibody, Tyrosine-protein kinase RSE antibody, Tyrosine-protein kinase SKY antibody, Tyrosine-protein kinase TIF antibody

UniProt: Q06418

Pathways: RTK Signalweg