TRIB1 Antikörper (AA 3-91)

Produktnummer ABIN7173357

Der Kaninchen Polyklonal Anti-TRIB1-Antikörper wurde für WB, ELISA, IHC und IF validiert. Er ist geeignet, TRIB1 in Proben von Human zu detektieren.

Kurzübersicht für TRIB1 Antikörper (AA 3-91) (ABIN7173357)

Target: TRIB1 (Tribbles Homolog 1 (TRIB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-TRIB1 Antikörper

Bindungsspezifität: AA 3-91

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Tribbles homolog 1 protein (3-91AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TRIB1

Target: TRIB1 (Tribbles Homolog 1 (TRIB1))

Andere Bezeichnung: TRIB1

Hintergrund:

Background: Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).

Aliases: C8FW antibody, G-protein-coupled receptor-induced gene 2 protein antibody, GIG-2 antibody, GIG2 antibody, SKIP1 antibody, TRB-1 antibody, TRB1 antibody, Trib1 antibody, TRIB1_HUMAN antibody, Tribbles homolog 1 antibody

UniProt: Q96RU8

Pathways: Smooth Muscle Cell Migration