THO Complex 4 Antikörper (AA 186-240) (Biotin)

Produktnummer ABIN7172056

Dieses Anti-THO Complex 4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von THO Complex 4 in ELISA. Geeignet für Human.

Kurzübersicht für THO Complex 4 Antikörper (AA 186-240) (Biotin) (ABIN7172056)

Target: THO Complex 4 (THOC4)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THO Complex 4 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-THO Complex 4 Antikörper (Biotin)

Bindungsspezifität: AA 186-240

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human THO complex subunit 4 protein (186-240AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu THO Complex 4

Target: THO Complex 4 (THOC4)

Andere Bezeichnung: ALYREF

Hintergrund:

Background: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5\\\' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi\\\'s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production, ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA, proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability.

Aliases: Ally of AML-1 and LEF-1 antibody, Ally of AML1 and LEF1 antibody, ALY antibody, ALY/REF antibody, Aly/REF export factor antibody, BEF antibody, bZIP enhancing factor antibody, bZIP-enhancing factor BEF antibody, REF antibody, THO complex 4 antibody, THO complex subunit 4 antibody, Tho4 antibody, thoc4 antibody, THOC4_HUMAN antibody, Transcriptional coactivator Aly/REF antibody, Transcriptional coactivator antibody

UniProt: Q86V81