TRF2 Antikörper (AA 78-238) (Biotin)

Produktnummer ABIN7171734

Produktdetails anti-TRF2 Antikörper (Biotin)

Target: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Bindungsspezifität: AA 78-238

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRF2 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Telomeric repeat-binding factor 2 protein (78-238AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TRF2

Target: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Andere Bezeichnung: TERF2 (TERF2 Produkte)

Synonyme: TERF2 antikoerper, TRBF2 antikoerper, TRF2 antikoerper, trf2 antikoerper, telomeric repeat binding factor 2 antikoerper, telomeric repeat binding factor 2 L homeolog antikoerper, TERF2 antikoerper, Terf2 antikoerper, terf2.L antikoerper

Hintergrund:

Background: Binds the telomeric double-stranded 5\\\'-TTAGGG-3\\\' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5\\\'-TTAGGG-3\\\' repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3\\\' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.

Aliases: Telomeric DNA binding protein antibody, Telomeric DNA-binding protein antibody, Telomeric repeat binding factor 2 antibody, Telomeric repeat binding protein 2 antibody, Telomeric repeat-binding factor 2 antibody, TERF 2 antibody, Terf2 antibody, TERF2_HUMAN antibody, TRBF 2 antibody, TRBF2 antibody, TRF 2 antibody, TRF2 antibody, TTAGGG repeat binding factor 2 antibody, TTAGGG repeat-binding factor 2 antibody

UniProt: Q15554

Pathways: Zellzyklus, Telomere Maintenance