TNKS Antikörper (AA 35-130) (FITC)

Produktnummer ABIN7171498

Dieses Anti-TNKS-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TNKS in . Geeignet für Human.

Kurzübersicht für TNKS Antikörper (AA 35-130) (FITC) (ABIN7171498)

Target: TNKS (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNKS Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-TNKS Antikörper (FITC)

Bindungsspezifität: AA 35-130

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Tankyrase-1 protein (35-130AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TNKS

Target: TNKS (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS))

Andere Bezeichnung: TNKS

Hintergrund:

Background: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.

Aliases: ADP-ribosyltransferase diphtheria toxin-like 5 antibody, OTTHUMP00000115550 antibody, OTTHUMP00000224675 antibody, PARP 5a antibody, PARP5A antibody, PARPL antibody, pART5 antibody, Poly [ADP-ribose] polymerase 5A antibody, TANK 1 antibody, TANK1 antibody, Tankyrase 1 antibody, Tankyrase I antibody, Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase antibody, Tankyrase-1 antibody, Tankyrase1 antibody, TankyraseI antibody, TIN 1 antibody, TIN1 antibody, TINF 1 antibody, TINF1 antibody, TNKS 1 antibody, TNKS antibody, TNKS-1 antibody, TNKS1 antibody, TNKS1_HUMAN antibody, TRF1 interacting ankyrin related ADP ribose polymerase antibody, TRF1-interacting ankyrin-related ADP-ribose polymerase antibody

UniProt: O95271