SOCS3 Antikörper (AA 1-224)

Produktnummer ABIN7171000

Dieses Anti-SOCS3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SOCS3 in IHC, ELISA und IF. Geeignet für Human.

Kurzübersicht für SOCS3 Antikörper (AA 1-224) (ABIN7171000)

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-SOCS3 Antikörper

Bindungsspezifität: AA 1-224

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Suppressor of cytokine signaling 3 protein (1-224AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Andere Bezeichnung: SOCS3

Hintergrund:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.

Aliases: ATOD4 antibody, CIS 3 antibody, CIS-3 antibody, CIS3 antibody, Cish3 antibody, Cytokine induced SH2 protein 3 antibody, Cytokine-inducible SH2 protein 3 antibody, E2a Pbx1 target gene in fibroblasts 10 antibody, EF 10 antibody, MGC71791 antibody, SOCS 3 antibody, SOCS-3 antibody, Socs3 antibody, SOCS3_HUMAN antibody, SSI 3 antibody, SSI-3 antibody, SSI3 antibody, STAT induced STAT inhibitor 3 antibody, STAT-induced STAT inhibitor 3 antibody, Suppressor of cytokine signaling 3 antibody

UniProt: O14543

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus, Hepatitis C