U2AF2 Antikörper (AA 124-246)

Produktnummer ABIN7170633

Der Kaninchen Polyklonal Anti-U2AF2-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, U2AF2 in Proben von Human zu detektieren.

Kurzübersicht für U2AF2 Antikörper (AA 124-246) (ABIN7170633)

Target: U2AF2 (U2AF59) (U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser U2AF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-U2AF2 Antikörper

Bindungsspezifität: AA 124-246

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Splicing factor U2AF 65 kDa subunit protein (124-246AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu U2AF2

Target: U2AF2 (U2AF59) (U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59))

Andere Bezeichnung: U2AF2

Hintergrund:

Background: Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.

Aliases: hU2AF(65) antibody, hU2AF65 antibody, Splicing factor U2AF 65 kDa subunit antibody, U2 (RNU2) small nuclear RNA auxiliary factor 2 antibody, U2 auxiliary factor 65 kDa subunit antibody, U2 small nuclear ribonucleoprotein auxiliary factor (65kD) antibody, U2 small nuclear RNA auxiliary factor 2 antibody, U2 snRNP auxiliary factor large subunit antibody, U2af2 antibody, U2AF2_HUMAN antibody, U2AF65 antibody

UniProt: P26368