SMUG1 Antikörper (AA 1-177) (Biotin)

Produktnummer ABIN7169741

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SMUG1 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SMUG1 Antikörper (AA 1-177) (Biotin) (ABIN7169741)

Target: SMUG1 (Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1 (SMUG1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMUG1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-SMUG1 Antikörper (Biotin)

Bindungsspezifität: AA 1-177

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Single-strand selective monofunctional uracil DNA glycosylase protein (1-177AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SMUG1

Target: SMUG1 (Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1 (SMUG1))

Andere Bezeichnung: SMUG1

Hintergrund:

Background: Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.

Aliases: FDG antibody, HMUDG antibody, MGC104370 antibody, Single strand selective monofunctional uracil DNA glycosylase 1 antibody, Single strand selective monofunctional uracil DNA glycosylase antibody, Single-strand selective monofunctional uracil DNA glycosylase antibody, SMUG 1 antibody, Smug1 antibody, SMUG1 protein antibody, SMUG1_HUMAN antibody, UNG 3 antibody, UNG3 antibody

UniProt: Q53HV7

Pathways: DNA Reparatur