SH2D1A Antikörper (AA 11-124) (Biotin)

Produktnummer ABIN7169450

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SH2D1A in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SH2D1A Antikörper (AA 11-124) (Biotin) (ABIN7169450)

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SH2D1A Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-SH2D1A Antikörper (Biotin)

Bindungsspezifität: AA 11-124

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human SH2 domain-containing protein 1A protein (11-124AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SH2D1A

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Andere Bezeichnung: SH2D1A

Hintergrund:

Background: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.

Aliases: DSHP antibody, Duncan disease SH2 protein antibody, Duncan disease SH2-protein antibody, EBVS antibody, IMD5 antibody, LYP antibody, MTCP1 antibody, SAP antibody, SAP/SH2D1A antibody, SH2 domain containing 1A antibody, SH2 domain protein 1A antibody, SH2 domain-containing protein 1A antibody, SH21A_HUMAN antibody, SH2D1A antibody, Signaling lymphocyte activation molecule associated protein antibody, Signaling lymphocytic activation molecule-associated protein antibody, SLAM associated protein antibody, SLAM associated protein/SH2 domain protein 1A antibody, SLAM-associated protein antibody, T cell signal transduction molecule SAP antibody, T-cell signal transduction molecule SAP antibody, XLP antibody, XLPD antibody

UniProt: O60880

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process