SRRT Antikörper (AA 627-876)

Produktnummer ABIN7169355

Der Kaninchen Polyklonal Anti-SRRT-Antikörper wurde für ELISA und IHC validiert. Er ist geeignet, SRRT in Proben von Human zu detektieren.

Kurzübersicht für SRRT Antikörper (AA 627-876) (ABIN7169355)

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRRT Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-SRRT Antikörper

Bindungsspezifität: AA 627-876

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Serrate RNA effector molecule homolog protein (627-876AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SRRT

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Andere Bezeichnung: SRRT

Hintergrund:

Background: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA), however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Aliases: ARS2 protein antibody, Arsenate resistance protein ARS2 antibody, Arsenite resistance protein 2 antibody, Arsenite resistance protein antibody, Arsenite-resistance protein 2 antibody, ASR2 antibody, MGC126427 antibody, Serrate antibody, Serrate RNA effector molecule antibody, Serrate RNA effector molecule homolog (Arabidopsis) antibody, Serrate RNA effector molecule homolog antibody, SRRT antibody, SRRT_HUMAN antibody

UniProt: Q9BXP5

Pathways: Notch Signalweg, Stem Cell Maintenance