ULK3 Antikörper (AA 44-240)

Produktnummer ABIN7169213

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ULK3 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ULK3 Antikörper (AA 44-240) (ABIN7169213)

Target: ULK3 (Unc-51-Like Kinase 3 (ULK3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ULK3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-ULK3 Antikörper

Bindungsspezifität: AA 44-240

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Serine/threonine-protein kinase ULK3 protein (44-240AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ULK3

Target: ULK3 (Unc-51-Like Kinase 3 (ULK3))

Andere Bezeichnung: ULK3

Hintergrund:

Background: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.

Aliases: DKFZP434C131 antibody, FLJ90566 antibody, Serine/threonine-protein kinase ULK3 antibody, Ulk3 antibody, ULK3_HUMAN antibody, unc 51 like kinase 3 (C. elegans) antibody, Unc-51-like kinase 3 antibody

UniProt: Q6PHR2